منابع مشابه
Nalidixic Acid: microbiological and clinical studies on urinary infections in children.
A series of alkyl-substituted naphthyridine derivatives was synthesized by Lesher, Froelich, Gruett, Bailey, and Brundage (1962) in the early 1960's, and one of these, nalidixic acid (1-ethyl-7methyl-i, 8 naphthyridine-4-one-3 carboxylic acid), was found to have considerable activity in vitro against the Gram-negative bacteria commonly met with in urinary infections. High urinary levels were ob...
متن کاملExperience with nalidixic Acid in the treatment of urinary tract infections of children.
The drug has been shown to be effective in combating most Gram-negative micro-organisms, including Esch. coli, Klebsiella, and B. proteus, in vitro and in vivo (Barlow, 1963; Buchbinder, Webb, and McCabe, 1962; Lesher et al., 1962), though Pseudomnonas appears to be more resistant (Barlow, 1963; Buchbinder et al., 1962; Harper and Howse, 1964). Gram-positive bacteria such as staphylococci, ente...
متن کاملComparative Study of the Levels of Nalidixic Acid in Plasma and Urine and Its Antibacterial Activity in Urinary Infections
NALIDIXIC ACID, one of a series of 1, 8naphthyridine derivatives with antibacterial activity was synthesised by Lesher, Froelich, Gruett, Bailey and Brundage (1962). Chemically it is l-ethyl-7-methyl-1, 8-naphthyridine-4-one3-carboxylic acid. The pharmacology and toxicology have been documented by Ward-McQuaid, Jichlinski and Macis (1963) and Lishman and Swinney (1963), based on unpublished inf...
متن کاملNalidixic acid: an antibacterial paradox.
Nalidixic acid was found to be most bactericidal against various species of gram-negative bacteria at 50 to 200 mug/ml. With all species tested, increases in the concentration of nalidixic acid above this range reduced, rather than increased, its bactericidal effect so that, at levels in the region of 400 mug/ml, the drug was relatively bacteriostatic. Therefore, the mode of action of nalidixic...
متن کاملPhotochemical Reaction of Nalidixic Acid in Methanol
The photochemical reactions of methanolic nalidixic acid (NAL) solution in the absence and in the presence of air have been investigated using 300 nm UV light. From the reactions, 1-ethyl-7-methyl-4-oxo-4-hydro-1,8naphthyridine (EMDN), formic acid, and formaldehyde are produced. In the presence of air, hydrogen peroxide is also detected along with the products listed above. The presence of oxyg...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: BMJ
سال: 1963
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.2.5368.1311